Maspin plays an essential role in early embryonic development
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Maspin plays an essential role in early embryonic development.
Maspin (Mp) is a member of the serpin family with inhibitory functions against cell migration, metastasis and angiogenesis. To identify its role in embryonic development in vivo, we generated maspin knockout mice by gene targeting. In this study, we showed that homozygous loss of maspin expression was lethal at the peri-implantation stage. Maspin was specifically expressed in the visceral endod...
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ژورنال
عنوان ژورنال: Development
سال: 2004
ISSN: 1477-9129,0950-1991
DOI: 10.1242/dev.01048